Insulin

The metabolism in the body requires the hormone insulin. It transports the glucose from the blood into the cells where it is needed for energy production. The carbohydrates from food are broken down in the intestines, among other things into glucose. These glucose molecules enter the blood and are distributed from there to the cells of all parts of the body. The insulin opens the cells for the sugar molecules.

If you are a person with diabetes who needs insulin injections, this means that your body cannot produce enough of its own insulin. If there is a lack of insulin blood glucose levels will increase rapidly and can result in a ketoacidosis or even in a ketoacidotic coma. However, thanks to individually tailored insulin therapy, you can lead a largely unrestricted, active and healthy life. 

Self-responsible specialist

Insulin-dependent people with diabetes have to know exactly about action of the used insulins. But more than that. They need to understand how insulin, diet and activity work together to ensure that the required insulin level is always present in the blood. Intensive education is necessary to enable the self-responsible specialist to manage his life nearly like a healthy individual. This is important for both people with type 1 and type 2 diabetes. Different actions of insulin enable people to reach a high flexibility including high level of training activity. 

Adaption of insulin delivery to daily life situations

Whenever food intake or training activities differ a lot from standard daily life situations the insulin dose has to be adequately adapted. You can control your measures by testing blood glucose more often. If your blood glucose levels keep to be elevated for a longer period of time it is necessary to adapt the insulin dose following the concepts of your physician.

The production of Insulin

Insulin was first discovered in the pancreas and explored by two Canadian scientists named Dr. Rederick G. Banting and Charles H. Best.in the year 1921. Until the Eigthies of the last century insulin was produced using pancreata from pigs and cattle. Today almost all people with diabetes use biosynthetic produced regular insulin which is processed from recombinant genetic technology. Microorganisms like medicinal yeast are programmed to produce insulin which is identical with human insulin.

Types of Insulin

There are 2 main types of insulin: regular insulin and insulin analogues. Within both groups we distinguish between short-, middle-, long-acting and mixes insulins. They differenciate from each in terms of taking effect, when strongest effect is reached and how long the effect takes place. The reason for that is that they are slightly different in structure and therefore the resorption form fatty tissue into blood takes different time. The choice of insulin for a person with diabetes depends on lifestyle and needs. The decision for the insulin of choice is taken together from the physician and the well-educated person concerned.

More information:
Types of insulin therapy
Injection technique

In Germany, only the U100 insulin is still available (100 I.U. insulin is dissolved in 1 ml liquid). However, when traveling abroad, keep in mind that there are other concentrations (U40).

In Germany it is still offered by some pharmacies, which still mix the insulin themselves.

Make sure that you use the correct insulin concentration to avoid over- or underdosing!

Delayed insulin covers the body's constant basic need for insulin and is therefore also called basal insulin (fasting insulin).

There are the following main groups of long-acting insulins:

Regular and NPH insulins with delayed action can be mixed. The resulting NPH mixes insulins can be adapted to the individual needs of a person with diabetes. The pharmacodynamics of both components will stay the same.